Inulin from Dioscorea esculenta and Metformin in Combination Ameliorates Metabolic Syndrome in Rats by Altering Short-Chain Fatty Acids
Fatmawati D., Soetoko A.S., Ardiansyah F., Cahyaningrum D.
Abstract
Metabolic syndrome (MetS) increases the risk of diabetes and cardiovascular diseases. Several studies have highlighted the role of inulin and metformin in metabolic disorders since insulin resistance and gut microbiota are known to play a role in them. This study was aimed at assessing the effect of the combination of inulin from Dioscorea esculenta (DC) and metformin on insulin resistance, lipid profile, and short-chain fatty acids (SCFAs) in the MetS rat model. Twenty-five rats were divided into 5 groups consisting of one untreated group and four treated groups that received a single dose of streptozotocin (STZ) and a high-fat diet (HFD) for 35 days to induce MetS. Starting on day 14, three of the treated groups; I, M, and Com were administered inulin DC (360 mg/day, orally), metformin (100 mg/KgBW, intraperitoneally), and a combination of inulin DC and metformin (inulin DC; 360 mg/day, orally and metformin; 100 mg/KgBW, intraperioteneally), respectively. The biochemical parameters (HOMA-IR, serum insulin, glucose, HbA1C, cholesterol, triglyceride (TG), low-density lipoprotein (LDL) and SCFAs (butyric acid (BA), propionic acid (PA), and acetic acid (AA)) were evaluated. This study found that the combination of inulin DC and metformin decreased HOMA-IR, serum insulin, glucose, HbA1C, cholesterol, TG, LDL and increased butyric acid and propionic acid but not acetic acid in MetS model. In conclusion, the combination of inulin DC and metformin ameliorates insulin resistance and the lipid profile in MetS model rats was associated with the changes in SCFAs.
Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway
Abraham M.A., Abraham M.A., Bauer P.V., Bauer P.V., Dranse H.J., Duca F.A., Lam T.K.T., Lam T.K.T., Lam T.K.T., O'Brien C.A., O'Brien C.A., Puri A., Rasmussen B.A., Rasmussen B.A., Waise T.M.Z.
Proinflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in human adipocytes is mediated by MEK, C/EBPβ, and NF-κB/RelA
Breton A., Breton A., Chapman K.E., Donadeu F.X., Donadeu F.X., Esteves C.L., Kelly V., Peault B., Peault B., Seckl J.R., Taylor A.I., West C.C., West C.C.
Metformin and inflammation: Its potential beyond glucose-lowering effect
Saisho Y.
Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptin-related Pathways Mediated by Gut Microbiota
Feng Y., Feng Y., Hao Y., Hu Y., Li B., Li J., Li J., Liu F., Liu F., Lyu N., Lyu N., Ma Y., Ma Y., Song X., Song X., Song X., Xue Y., Zhong L., Zhu B., Zhu B., Zhu B., Zhu B.
Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study
Hong J., Jiao Z., Liu Y., Meng L., Song J., Tian R., Yu M., Zhang Y., Zhao J., Zhou D.
Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome
Barry N.A., Cardone R.L., Cline G.W., Goodman A.L., Kibbey R.G., Peng L., Perry R.J., Petersen K.F., Petersen K.F., Shulman G.I., Shulman G.I., Zhang D.
The short-chain fatty acid acetate in body weight control and insulin sensitivity
Blaak E.E., Canfora E.E., Hernandez M.A.G., Jocken J.W.E., Blaak E.E., Canfora E.E., Hernandez M.A.G., Jocken J.W.E.
Dietary inulin alleviates diverse stages of type 2 diabetes mellitus: Via anti-inflammation and modulating gut microbiota in db/db mice
Dong X., Dong Y., He L., He L., Lei H., Li K., Li K., Li X., Liu P., Sha L., Wang H., Wang Z., Xue J., Yang X., Zhang L., Zhang X., Zhu L.
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice
Blaut M., Fankhanel M., Gohlke S., Klaus S., Petzke K.J., Postel A., Rumberger S., Schulz T.J., Schumann S., Stuhlmann C., Weitkunat K., Woting A.
Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure
Bargiela R., Campoy C., Ferrer M., Haange S.-B., Haange S.-B., Haange S.-B., Lanza F., Oberbach A., Oberbach A., Richter M., Ruiz A., Segura M.T., Seifert J., Suarez A., Till H., Till H., von Bergen M.
Widayati E., Tyagita N., Safitri A.H.
Tropical Journal of Natural Product Research
Adebayo A.H., Lawal A.K., Yakubu O.F., Koyejo O.D., Oluwaloni F.O.
Tropical Journal of Natural Product Research
Susilo A., Luthfian A., Hakiki D.N., Rismaya R., Sulistyawati E.Y.E.
Canrea Journal Food Technology Nutritions and Culinary Journal
Melteras M., Lebot V., Abraham K.
Genetic Resources and Crop Evolution
