Clitorea ternatea flower extract induces platelet-derived growth factor (Pdgf) and gpx gene overexpression in ultraviolet (uv) b irradiationinduced collagen loss

Darlan D.M., Chodidjah, Putra A., Thomas S., Trisnadi S., Amalina N.D., Putri R.S., Irawan R.C.

Abstract

Aim To determine the effect of Clitorea ternatea flower extract (CTFE) in the gel dosage form on the expression of GPx and platelet- derived growth factor (PDGF) in ultraviolet (UV) - B irradiation- induced collagen loss rat model. Methods This is experimental research with post-test control group design. Twenty healthy male Wistar rats were divided into four treatment groups: A sham group, UVB control group, two treatment groups with gel of CTFE 5% and gel of CTFE 10%, respectively. Each group was treated with UVB at 302 nm with a MED of 160 mJ/cm2 for 5 days, whereas the sham group did not receive UVB. In the treatment groups CTFE 5% and CTFE 10% gel were given on the 6th to the 14th day. On day 14 all treatment groups were terminated, and GPx and PDGF gene expression were analysed using qRT-PCR. Results In the group of gel of CTFE 10%, there was a significant increase in GPx gene expression (9.51±1.83) and PDGF (4.36±1.18) compared to the UVB control group which had GPx and PDGF gene expression of 4.90±1.64) and 0.032±0.01, respectively. Conclusion The administration of CTFE gel showed an increase of the expression of GPx and PDGF genes on UVB irradiationinduced collagen loss rat model.

Journal
Medicinski Glasnik
Page Range
15-21
Publication date
2023
Total citations
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10.17392/1530-22