The effect of the ethanol extract of Typhonium flagelliforme on apoptosis adenocarcinoma mamma cells in C3H mice
Susanto H., Chodidjah, Ekawuyung P., Dharmana E.
Abstract
Malignancy cause high impact in mortality in worldwide. Typhonium Flagelliforme have been known to improve the immune system. The aims of this study was to determine the effects of Typhonium Flagelliforme on the tumor necrosis factor alpha (TNF-α) level and percentage of apoptotic cells in mice tumor The post test study design with randomized control group of 24 C3H mice with tumor were divided into 4 groups: I (control), 2; 3; and 4 (treatment). All treatment were given 0.2 cc of extract at the dose of 200, 400 and 800 mg/kgBW respectively for 30 days. TNF-α level was from tumor tissue were measured using ELISA methods, and percentage of apoptotic cells from tumor tissue were determined using immunohistochemistry assay with TUNEL antibody. The mean difference of TNF-α expression was tested using Anova at the significant level of 0.05. Apoptotic cells was analyzed by Mann Whitney. The result indicate that average of TNF α level in the treated groups were higher than those of control group (p<0.05). The percentage of apoptotic cells at the dose 200 mg/KgBW was higher than that of control group, groups 2 and 3(P<0.05). In conclusion, Typhonium Flagelliforme can increase in the percentage of apoptosis cells but not in the levels of TNF α.
The Ethyl Acetate Extract of Mangosteen Peel Cream Attenuates Ultraviolet B Radiation-Induced Apoptotic Cell Death Via Antioxidant Effect By Regulation TNF-Α and Caspase 3 in Guinea Pig Skin
Dirgahayu P., Harlisa P., Harlisa P., Purwanto B., Sentono H.K., Soetrisno
Antibacterial and antioxidant activities of Typhonium flagelliforme (Lodd.) Blume tuber
Abdul A.B., Al-Zubairi A.S., Al-Zubairi A.S., Elhassan M.M., Mohan S., Wahab S.I.A., Yousif M.
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Lee N.K., Lee S.Y.
In vitro models of the intestinal barrier: The report and recommendations of ECVAM workshop 461,2
Artusson P., Brayden D., Chesne C., Fabre G., Gires P., Guillou F., Le Ferrec E., Rousset M., Rubas W., Scarino M.-L.
Caspase family proteases and apoptosis
Cong R.-S., Fan T.-J., Han L.-H., Liang J., Cong R.-S., Fan T.-J., Han L.-H., Liang J.
The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system
Aalinkeel R., Kandaswami C., Mahajan S., Nair H., Nair M.P., Nair M.P., Reynolds J.L., Schwartz S.A.
Detection of apoptosis by TUNEL assay
Kioussi C., Kyryachenko S., Kyrylkova K., Leid M.
In Vitro Cytotoxic Study and Detection of Apoptosis on Breast Cancer Cell lines MDA-MB 231 after Exposed to Azadirachta Indica A. Juss (neem) Extract
Arisanty D.
A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathways
Afaq F., Johnson J.J., Mukhtar H., Mukhtar H., Suh Y.
Typhonium flagelliforme decreases protein expression in murine breast cancer
Chodidjah Nasihun T, Goenarwo E., Widayati E
Tan S.F., Naimat F., Looi S.Y., Hamid H., Ng K.W.
Journal of Traditional Chinese Medical Sciences
Muntaha S., Islam M.J., Das A.K.
Bangladesh Journal of Medical Science
