Hypoxic secretome mesenchymal stem cells inhibiting interleukin-6 expression prevent oxidative stress in type 1 diabetes mellitus
Putra A., Wibowo J.W., Amalina N.D., Irawan R.C.S., Utami A.
Abstract
Aim Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the chronic inflammation of the pancreatic islets of Langerhans. Hyperglycaemia leads to suppressed antioxidant enzyme and increased inflammation in the pancreatic cell, resul-ting in pancreatic cell death. Hypoxic secretome mesenchymal stem cells (HS-MSCs) are soluble molecules secreted by MSCS that have the antiinflammation ability by secreting various cytoki-nes including IL-10 and TGF-β which potent as a promising therapeutic modality for T1DM. This study aims to investigate the role of HS-MSCs in regulating superoxide dismutase (SOD) and caspase-3 gene expression in T1DM model. Methods Twenty male Wistar rats (6 to 8 weeks old) were randomly divided into four groups (sham, control, HS-MSCs 0.5 mL and HS-MSCs 1 mL intraperitoneal treatment group). Streptozo-tocin (STZ) 60mg/kgBB was conducted once on day 1, HS-MSCs 0.5mL (T1) and HS-MSCs 1 mL (T2) were administrated intrape-ritoneally on day 7, 14, and 21 after STZ administration. The rats were sacrificed on day 28; the gene expression of SOD and IL-6 was analysed by qRT-PCR. Results This study showed that the ratio of SOD significantly increased in HS-MSCs treatment associated with suppression of IL-6 gene expression. Conclusion HS-MSCs administration suppresses oxidative stress and inflammation by up regulating SOD and inhibiting IL-6 to control T1DM.
Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes
Carvalho S.N., Cortez E., de Carvalho L., Dias I., Pinheiro D., Ribeiro Silva K., Stumbo A.C., Thole A.
IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice
Chao C., Hu Y., Huang J., Huang J., Li Y., Li Y., Pearson J.A., Pearson J.A., Peng J., Tai N., Tan Q., Tan Q., Wen L., Wong F.S., Xing Y., Xing Y., Zhang L., Zhang L., Zhang L., Zhou Z.
Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors
Rose-John S., Schmidt-Arras D.
Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation
Comella J.X., di Penta A., di Penta A., Errea O., Escala N., Fernandez-Diez B., Moreno B., Reix S., Vandenbroeck K., Vandenbroeck K., Villanueva M., Villoslada P.
Role of mesenchymal stem cells in counteracting oxidative stress—related neurodegeneration
Angeloni C., Gatti M., Hrelia S., Maraldi T., Prata C.
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids
Caporaso R., Catanzaro M., Dacrema M., Daglia M., Fagiani F., Fagiani F., Govoni S., Lanni C., Racchi M., Romanoni I., Rosini M., Serafini M.M., Serafini M.M., Serafini M.M., Simoni E.
The CD4+CD25+FoxP3+ Regulatory T Cells Regulated by MSCs Suppress Plasma Cells in a Mouse Model of Allergic Rhinitis
Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J.
Nrf2 signaling pathway: Pivotal roles in inflammation
Ahmed S.M.U., Luo L., Luo L., Namani A., Tang X., Wang X.J., Ahmed S.M.U., Luo L., Luo L., Namani A., Tang X., Wang X.J.
Role of Nrf2 in oxidative stress and toxicity
Ma Q., Ma Q., Ma Q., Ma Q., Ma Q., Ma Q.
Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated Protein quality control in cardiomyocytes
Cui T., Janicki J.S., Lai Y., Wang X.
Popevic S., Stjepanovic M., Ilic B., Maric N., Belic S., Dimic-Janjic S., Sekulovic Radovanovic I.
Diagnostics
Sumarawati T., Putra A., Trisnadi S., Amalina N.D., Setiawan E., Hermansyah D., Angelina J.
Medicinski Glasnik
Sumarawati T., Putra A., Trisnadi S., Amalina N.D., Priyantini S., Muhar A.M., Alif I., Prasetio A., Irawan R.C.S., Widyaningsih W.
Trends in Sciences
Putra A., Sarosa H., Trisnadi S., Amalina N.D., Mulyani S.P., Ibrahim S., Dewi A.M., Chodijah C.
Biosaintifika
Prayitno A., Wasita B., Setiamika M., Widyaningsih V., Tamtomo D.G., Soetrisno S., Kadarullah O.
Trends in Sciences
Dirja B.T., Putra A., Amalina N.D., Wardoyo E.H.
Trends in Sciences
Prayitno A., Soetrisno, Laqif A., Kusumo M.H.B.
Archives of Medical Science
Pezeshki P.S.
Comprehensive Hematology and Stem Cell Research Volume 1 5
