Irritation test and melanin whitening cream epigallocatechin gallate green tea leaf with mexameter and self-assessment
Yuyun D.A.N., Widyaningrum N., Sari B.N., Fathnin F.H.
Abstract
Background: Green tea (Camelia sinensis L.) contains flavonoids consisting of Epigallocatechin gallate (EGCG) which functions as whitening, anti-acne, antioxidant, anti-inflammatory. Previous studies have shown that EGCG with a concentration of 6% is the optimum concentration in cream formulations (Widyaningrum, 2015b). Phase One Clinical Test was conducted to determine the safety of cream preparations with irritation as a benchmark and continued to test its effectiveness as a whitening cream on 20 respondents aged 17-45 years. Material and Methods: The research method employed was the Open Test. The results of the study for 21 days after applying the EGCG anti-acne cream were assessed using a mexa-meter and self-assessment. Result: The erythema assessment showed that the preparation did not cause irritation in the absence of erythema and for the melanin assessment, the results were not significant with p Value 0.376 (<0,05) with no changes in the melanin index. The results of the irritation test were supported by the findings of self-assessment which revealed that all self-assessment parameters were not significant and there was no irritation (p 0,317). Conclusion: Based on the results of the study, it could be concluded that EGCG whitening cream did not cause irritation for 21 days. The results of the melanin test formula for this whitening cream preparation were able to provide a skin whitening effect.
Krim ekstrak teh hijau 20% (Camellia sinensis) mencegah peningkatan jumlah melanin sama efektif dengan krim hidrokuinon 4% pada kulit marmut (Cavia porcellus) yang dipajan sinar ultraviolet B
Pangkahila W., Puspitasari P., Putra Wiraguna A., Pangkahila W., Puspitasari P., Putra Wiraguna A.
No Title
Fudholi A., Prawita Setyowati E., Widyaningrum N., Fudholi A., Prawita Setyowati E., Widyaningrum N.
BUFFER AND EMULSIFIER OPTIMIZATION IN CREAM WITH ITS ANTIBACTERIAL ACTIVITY AND SENSITIVITY
Fudholi A., Setyowati E. P., Widyaningrum N., Fudholi A., Setyowati E. P., Widyaningrum N.
Skin erythema and pigmentation: a review of optical assessment techniques
Abdlaty R., Fang Q., Farrell T., Hayward J., Abdlaty R., Fang Q., Farrell T., Hayward J.
Evaluation and Drug Efficiency and Savety (Clinical Testing)
Stabilitas katekin teh hijau dalam daun teh komersial selama penyimpanan selama 6 bulan
CE L., M F., SU L., CE L., M F., SU L.
S. & Setyowati, E. P. Stability of Epigallocatechin Gallate (EGCG) from Green Tea (Camellia sinensis) and its Antibacterial Activity against Staphylococcus epidermidis ATCC 35984 and Propionibacterium acnes ATCC 6919
Fudholi A., Widyaningr N., Fudholi A., Setyowati E. P., Widyaningr N.
Formulation and Irritation Test for Combination Gel Preparations of Kencur (Kaempferia galanga L.) Rhizome Extract and Centella asiatica (L.) Urban Ethanol Extract. (Centella asiatica (L.) Urban)
Febriani A., Maruya I., Sulistyaningsih F., Febriani A., Maruya I., Sulistyaningsih F.
Standardadization and skin irritation potential of herbal analgesic cream containing nigella sativa seed oil
Atiq-U-rehman, Ferheen S., Imran H., Khan R.A., Sohail T., Yasmeen S., Atiq-U-rehman, Ferheen S., Imran H., Khan R.A., Sohail T., Yasmeen S.
No Title
Oktaria R., Rahmanisa S.
