The Potential of UV-B Irradiated Oyster Mushroom (Pleurotus ostreatus) Powder on Plasma Glucose and TNF-α Levels in Type 2 Diabetic Rats
Hussaana A., Chodidjah C., Hasanah S.N.
Abstract
The study aimed to investigate the impact of UV-B irradiated oyster mushroom powder (referred to as Oyster-D) on blood sugar and TNF-α levels in type 2 diabetic rats induced with streptozotocin (STZ) over 28 days. Twenty-five male rats were divided into five groups: (A) negative control with STZ induction, (B), (C), (D) treated with Oyster-D at doses of 2000 IU, 4000 IU, 8000 IU, and (E) a normal group without STZ induction. Following treatment, blood samples were collected to analyze fasting plasma glucose (FPG) levels using the GOD-PAP method, while TNF-α levels were assessed using the ELISA method. Statistical analysis included One-Way ANOVA and Post Hoc LSD for mean FPG level differences and Kruskal Wallis and Mann-Whitney tests for mean TNF-α levels. The results revealed a significant reduction in mean FPG levels after treatment in the negative control compared to the Oyster-D treatment groups at doses of 2000 IU, 4000 IU, and 8000 IU (p<0.05). Additionally, a notable increase in mean TNF-α levels was observed in the negative control group relative to the Oyster-D treatment group at a dose of 8000 IU (p<0.05). Overall, Oyster-D exhibited potential in reducing blood sugar levels and elevating TNF-α levels in male Wistar rats induced with STZ, suggesting its possible utility in managing hyperglycemia and TNF-α expression in diabetes.
Perbedaan Kadar Tumor Necrosis Factor-Alfa Antara Diabetes Mellitus Tipe 2 Terkontrol Dengan Tidak Terkontrol
Yuniarti E.
Lipid peroxidation in cell death
Gaschler M.M., Stockwell B.R.
Ostreolysin A/pleurotolysin B and equinatoxins: Structure, function and pathophysiological effects of these pore-forming proteins
Benoit E., Frangez R., Molgo J., Suput D.
Vitamin D and diabetes mellitus. Hormones. 2014;13(2):163–81. membrane pores induced by ostreolysin A/pleurotolysin B, binary pore-forming proteins from the oyster mushroom
Harinarayan CV.
Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling
Dudhgaonkar S., Jedinak A., Simon J., Sliva D., Sliva D., Sliva D., Wu Q.-L.
No Title
Hussana A
Evaluation of Clitoria ternatea L. Flower Extract in Preventing Complications of Diabetes Mellitus
Chodidjah C., Dewi I., Hussaana A.
Role of vitamin D on glycemic control and oxidative stress in type 2 diabetes mellitus
Alkady M.M., Ibrahim I.M., Saif-Elnasr M.
Analysis of Vitamin D in Patients with Diabetes Mellitus Type 2
Aman AM., Bahrun U, Pakasi RD, Sanda A
Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes
Gerstein H.C., Hanley A.J., Hanley A.J., Harris S.B., Kayaniyil S., Knight J.A., Knight J.A., Perkins B.A., Qi Y., Retnakaran R., Vieth R., Vieth R., Zinman B., Zinman B.
Taufiq H., Hussaana A., Pradana D., Agustina T., Aulia I., Revoni F., Dea A.
Indonesian Journal of Pharmacy
