Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis
Indarto D., Wasita B., Cilmiaty R.A.R., Wardani A.T.W., Purwanto B.
Abstract
Background: Acute bacterial rhinosinusitis is a common complication that require antibiotic therapy to recover promptly. To avoid the emergence and spread of antibiotic-resistant bacteria, Ethanol extract of moringa leaves (EEDK) contains active ingredients that serve as antioxidants that can help restore redox metabolic balance and can reduce excess free radicals so as to prevent oxidative stress and speed healing. Materials and Method: Effect of moringa leaves ethanol was evaluated in difference day post treatment, day 7<sup>th</sup> and day 10<sup>th</sup>. The level of TNF-a and IL-8 from each treatment group in Staphylococcus aureus rhinosinusitis induced rat was evaluated using ELISA compared to control group. Data were analyzed using SPSS 25.0 for Windows. Result: The results of the analysis of different tests of T-Test independence can be concluded that there is decrease in the average level of TNF-α on the 7th day with the 10th day in the P2 and P4 groups there is significant difference (p-value = 0.000), while the P3 group decreased the level of TNF-α on the 7th day with the 10th day there was no significant difference (p-value = 0.630), while the results of the il-8 independence difference in the average il-8 level decrease on the 7th day with the 10th day in Group P2, P3, P4 there is a significant difference (p-value =0.000). Conclusion: The combination of Amoxicillin 27 mg/day and EEDK 100mg/kg is better at decreasing TNF-α and IL-8 levels during 10 days of administration. EEDK can be used as an adjuvant therapy for acute bacterial rhinosinusitis.
The Effect of Kelor Leaves (Moringa oleifera) Ethanol Extract on Serum Uric Acid and Tumor Necrosis Factor-α of Hyperuricemic White Rats (Rattus norvegicus)
Wahyu Pribadi F., Widiartini C.
Moringa oleifera and their phytonanoparticles: Potential antiproliferative agents against cancer
Anand K., Chuturgoon A.A., Gengan R.M., Tiloke C., Tiloke C.
Anti-inflammatory effect of moringa oleifera lam. Leaf extract on uvb-irradiated human keratinocytes
Engsuwan J., Ingkaninan K., Limpeanchob N., Waranuch N.
Antibacterial effect (in vitro) of moringa oleifera and annona muricata against gram positive and gram negative bacteria
Angelo A.M., Costa R.A., Mourao J.A., Vieira G.H.F., Vieira R.H.S.F.
Bioactive flavonoids in Moringa oleifera and their health-promoting properties
Chen X., Lin M., Zhang J., Chen X., Lin M., Zhang J.
Infections of the ears, nose, throat, and sinuses
Deschler D.G., Durand M.L.
Acute and Chronic Rhinosinusitis, Pathophysiology and Treatment Both project View project Multi Drug View project Acute and Chronic Rhinosinusitis, Pathophysiology and Treatment
Choudhury Shimmi S., Iftikhar M, Mustafa M
Effectiveness and safety of short vs. long duration of antibiotic therapy for acute bacterial sinusitis: A meta-analysis of randomized trials
Falagas M.E., Falagas M.E., Falagas M.E., Grammatikos A.P., Karageorgopoulos D.E., Matthaiou D.K.
IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults
Benninger MS, Brook I, Brozek JL, Chow AW, Goldstein EJC, Hicks LA
The prevalence of bacterial infection in acute rhinosinusitis: A systematic review and meta-Analysis
Chandra R.K., Evans C.T., Evans C.T., Ference E.H., Kern R.C., Smith S.S., Tan B.K.
