The effect of Curcuma longa on fasting blood glucose, MMP-9 and IFN-γ in diabetes mellitus: an experimental study
Sumarawati T., Chodidjah, Ovaditya S.Z., Brilliantika S.P.
Abstract
Background: Turmeric (Curcuma longa) contains curcumin as an active ingredient that has ability as a potent antioxidant and antiinflammation. Turmeric extract can improve glucose level and surpress micro and microangiopathy complication in Diabetes Mellitus Type 2. The aim of this study was to investigate the role of turmeric extract administration on fasting glucose level, MMP-9, and IFN-γ. Methods: Experimental PostTest Only Control Group Design study was conducted. Twenty four Wistar rats aged 2 months weighing 180-200 grams were adapted for 2 days, divided into 4 groups randomly: negative control group induced by STZ-NA only (P1), positive control group induced by STZ-NA and received metformin 45mg/kgBW/day (P2), treatment group induced by STZ-NA and received turmeric extract 200mg/kgBW/day (K1), and ), treatment group induced by STZ-NA and received combination of metformin 22,5mg/kgBW/day and turmeric extract 100mg/kgBW/day. The levels of fasting glucose serum were measured by spectrophotometric method, while ELISA measured the levels of MMP-9 and IFN-γ. Results: Mean + SD Fasting blood glucose level was decreased respectively from K1, K2, P1 and P2 (277.00 + 4.00, 100.00 + 2.00, 98.04 + 3.00, 92.00 + 3.00 mg/dl). MMP-9 level was decreased respectively from K1, K2, P1 and P2 (653.09 + 18.00, 328.00 + 14.00, 156.00 + 4.00, 131.00 + 4.00 ng/ml). IFN–γ level was decreased respectively from K1, K2, P1 and P2 (300 + 16.00, 85.00 + 3.00, 61.05 + 2.04, 49.00 + 1.09 ng/ml.) Kruskal Wallis test for Fasting blood glucose, MMP-9, dan IFN–γ shows significant differences among groups. (p=0.004, p=0.004, dan p=0.004). Using post hoc test, all groups significantly differ with p=0.000. Conclusion: The administration of turmeric extract improves fasting glucose level, MMP-9, and IFN-γ in type 2 DM Wistar rats.
Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway
Cao L., Han J., Kumar Sah S., Xie Y., Zhi D.
Prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians
Mihardja L., Soegondo S., Soetrisno U.
Treatment of type 2 diabetes mellitus worldwide: Baseline patient characteristics in the global DISCOVER study
Charbonnel B., Chen H., Cid-Ruzafa J., Fenici P., Gomes M.B., Hammar N., Ji L., Khunti K., Kosiborod M., Kosiborod M., Nicolucci A., Pocock S.J., Rathmann W., Shestakova M.V., Shimomura I., Surmont F., Tang F., Watada H.
Curcumin alleviates diabetic retinopathy in experimental diabetic rats
Ke F., Lan M., Li D., Li D., Ling J., Tan K., Wang Y., Wu K., Yang F., Yu J.
Role of interferons in diabetic retinopathy
He Y, Jiang B, Li B-Y, Tan W, Yoshida S, Zou J-L
The effects of nanomicelle of curcumin on the matrix metalloproteinase (MMP-2, 9) activity and expression in patients with coronary artery disease (CAD): A randomized controlled clinical trial
Akhlaghi S., Dastani M., Hasanzadeh S., Kazemi-Oskuee R., Mogharrabi M., Rahimi H.R., Soukhtanloo M.
Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells
Babu M.S., Karunagaran D., Saja K., Sudhakaran P.R.
Efek Rimpang Kunyit (Curcuma longa L.) dan Bawang Putih (Allium sativum L.) terhadap Sensitivitas Insulin pada Tikus Galur Wistar
Sasongko LDN., Sigit JI, Sovia E, Sukandar EY
Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives
Ahmed T.A., Amjad M.W., Hussain F., Hussain Z., Khan S., Thu H.E.
Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?
Abdollahi E., Abdollahi E., Johnston T.P., Momtazi A.A., Sahebkar A., Sahebkar A.
Saini B., Grewal A.S., Gulati D.
Current Pharmaceutical Biotechnology
Nidom R.V., Indrasari S., Ansori A.N.M., Nidom A.N., Nidom C.A.
Pharmacognosy Journal
Rasyid H., Yustisia I., Hakim L., Prihantono, Nandana P.I.
Bali Medical Journal
Jakhmola V., Zainul R., Muchtaromah B., Ansori A.N.M., Fadholly A., Kusala M.K.J., Kharisma V.D., Rosadi I., Tamam M.B., Turista D.D.R., Murtadlo A.A.A., Rebezov M.
Journal of Medicinal and Chemical Sciences
Aminuddin A., Arfian N., Yusuf S., Syahrul S., Saleh A., Tahir T., Hamzah H., Raihan M., Setyawati A., Jafar N.
Jmir Research Protocols
Lebelo S.L., Phoswa W.N., Mokgalaboni K., Mashaba R.G.
Nutrients
