The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice
Yamaoka Y., Fasitasari M., Rejeki P.S., Kurniasari H., Lutvyani A., Sari D.R., Widiatmaja D.M., Meiliana I.D.
Abstract
Objectives: Noncommunicable disease (NCD) including obesity, cancer, and diabetes has become particular concern worldwide due to its morbidity and mortality which keep increasing annually. Adiponectin and insulin-like growth factor-1 (IGF-1) are known to be substances that are involved in the development of NCD. Several diet regimens have been developed to treat NCD, one of which is the ketogenic diet (KD). This study aimed to analyze the long-term KD effect on serum adiponectin and IGF-1 levels in mice. Methods: This study was a real experimental with post-test only controls group design. The subjects were 14 male mice (2-3 months, 20-30 g) were randomly divided into two groups, K1 (n=7, standard diet) and K2 (n=7, KD with a composition of 60% fat, 30% protein, and 10% fiber). All subjects were given diet intervention for 8 weeks ad libitum. Serum adiponectin and IGF levels were measured in post-intervention using Enzyme-Linked Immunosorbent Assay. Distribution of normality was analyzed by the Shapiro-Wilk Test, mean difference using Independent T-Test, and linear correlation using Pearson's Correlation Test. Data analysis was performed using Statistic Package for Social Science Version 16. Results: Serum adiponectin levels in K1 (0.080 ± 0.012) pg/mL and K2 (0.099 ± 0.005) pg/mL, with p=0.003. Serum IGF-1 levels in K1 (133.535 ± 25.702) ng/mL and K2 (109.987 ± 27.118) ng/mL, with p=0.121. Coefficient correlation between serum adiponectin and serum IGF-1 levels [r]=-0.401, with p=0.155. Conclusions: Long-term KD increases serum adiponectin levels and has no effect on serum IGF-1 levels. There was no significant correlation between serum adiponectin and serum IGF-1 levels.
Ketogenic diet in cancer prevention and therapy: Molecular targets and therapeutic opportunities
Alashqar A.M.D., Jamal D., Kamal A., Khater S., Mahmod A.I., Rashid H.M., Talib W.H., Waly M.
Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment
Angioli R., Bartolone M., Benedetti Panici P., Cianci S., Di Donato V., Fagotti A., Feole L., Luvero D., Marchetti C., Messina G., Plotti F., Scaletta G., Scambia G., Terranova C.
Adiponectin, a unique adipocyte-derived factor beyond hormones
Funahashi T., Maeda N., Matsuzawa Y., Shimomura I.
Long-term effects of a classic ketogenic diet on ghrelin and leptin concentration: A 12-month prospective study in a cohort of italian children and adults with GLUT1-deficiency syndrome and drug resistant epilepsy
Battezzati A., Bertoli S., De Amicis R., De Giorgis V., Ferraris C., Foppiani A., Leone A., Lessa C., Ravasenghi S., Ravella S., Tagliabue A., Trentani C., Veggiotti P., Veggiotti P.
A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet
Brandt-Wouters E., Lambrechts D.A.J.E., Majoie M.J.M., Majoie M.J.M., Verschuure P., Vles H.S.H., Vles H.S.H.
A Ketone Ester Drink Lowers Human Ghrelin and Appetite
Clarke K., Cox P.J., Cyranka M., de Wet H., Evans R.D., Stubbs B.J., Clarke K., Cox P.J., Cyranka M., de Wet H., Evans R.D., Stubbs B.J.
Ghrelin Plasma Levels After 1 Year of Ketogenic Diet in Children With Refractory Epilepsy
Biagini G., Borghi M., Costa A.M., Guerra A., Iughetti L., Lucchi C., Marchio M., Roli L., Trenti T.
An 8-week, low carbohydrate, high fat, ketogenic diet enhanced exhaustive exercise capacity in mice part 2: Effect on fatigue recovery, post-exercise biomarkers and anti-oxidation capacity
Huang Q., Huang Q., Huang Q., Liu C., Liu C., Ma S., Suzuki K., Tominaga T.
Potential application of ketogenic diet to metabolic status and exercise performance: A review
Ma S., Suzuki K., Ma S., Suzuki K.
The effect of ketogenic diet on behaviors and synaptic functions of naive mice
Chen Y.-J., Deng Y.-H., Huang J., Li Y.-Q., Sun X.-D., Sun X.-D., Wu C.-H., Xuan A., Zhang Y.-L., Zhao S.-T., Chen Y.-J., Deng Y.-H., Huang J., Li Y.-Q., Sun X.-D., Sun X.-D., Wu C.-H., Xuan A., Zhang Y.-L., Zhao S.-T.
Zhou F., Xie F., Zhou X., Wan S., Zhang L.
Science China Life Sciences
Messina G., Porro C., Polito R., Messina G., Tartaglia N., La Torre M.E., Benameur T., Cibelli G., Fiorelli A., Ambrosi A., Santini M.
Life
Hsu T.-R., Wang P.-Y., Lin W.-S., Lin S.-J., Liao P.-Y., Suresh D.
Advances in Nutrition
Talib W.H., Kamal A.K.S.
Pharmacia
Fu L., Lu C., DiKun K.M., Gudas L.J., Choi M.E., Tang X.-H.
Proceedings of the National Academy of Sciences of the United States of America
Lesmana R., Sugiharto, Rejeki P.S., Halim S., Pranoto A., Izzatunnisa N., Utami D.M., Widiatmaja D.M.
Sports
Lombardo M., Baldelli S., Aiello G., Muthanna F.M.S., Muthanna F.M.S., Campaci D., Mansilla Di Martino E.
Nutrients
Dutta S., Chatterjee M., Ganguly S.
Role of Herbal Medicines Management of Lifestyle Diseases
Lu N., Zhou X., Guo F.
Investigacion Clinica Venezuela
