Locally injected Mesenchymal Stem Cells optimize angiogenesis by regulating VEGF and CD31 expression in duodenal perforation
Wasita B., Putra A., Setiawan E., Purwanto B.
Abstract
Background: Duodenal perforation is considered as one of gastrointestinal emergency with high morbidity and mortality rate. The MSCs have the ability to improve wound healing by releasing several growth factors and anti-inflammatory cytokines to promote the angiogenesis process. This study aimed to investigate the role of MSCs in duodenal perforation wound healing. Methods: MSCs were isolated from rat umbilical cord and injected into duodenal wound site at doses of 1.5x10 [(Putra et al., 2018) 66 cells for T1 group and 3x10 [(Putra et al., 2018) 66 cells for T2 group. The control group was treated by local injection of normal saline. The VEGF levels were measured by Western blot, while CD31 expression was analyzed using immunohistochemistry staining. All examinations were assessed on days 3 and 7. Results: Results showed a significant increase in VEGF and CD31 expression on days 3 and 7 (p < 0,05). The VEGF level was significantly decreased on day 7 compared to day 3. Conclusion: The administration of MSCs improved the angiogenesis process in duodenal perforation by enhancing VEGF and CD31 expression.
PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review)
Chen Q., Fang J., Ma Y., Ying H.-Z., Yu C.-H., Zhang H.-H., Zhang S.-Z., Zhang W.-Y., Chen Q., Fang J., Ma Y., Ying H.-Z., Yu C.-H., Zhang H.-H., Zhang S.-Z., Zhang W.-Y.
Angiogenesis and liver fibrosis
Elpek G.O., Elpek G.O.
Angiogenesis and wound repair: When enough is enough
DiPietro L.A.
The expression level of TGF-β1, TGF-β3 and VEGF in transplanted oral mucosal and cutaneous wounds
Jiajia Zhao J.L.
Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)
Hu Y., Lertkiatmongkol P., Liao D., Liao D., Mei H., Newman P.J., Newman P.J.
Secretome from mesenchymal stem cells induces angiogenesis via Cyr61
An J., Estrada R., Lee M.-J., Li N., Sarojini H., Wang E.
Department, kuschner. Mesenchymal stem cell paracrine factors in vascular repair and regeneration
Braden T.T., Lakhani C.M., Manrai A.K., Patel C.J., Visscher P.M., Yang J.
Transition from inflammation to proliferation: a critical step during wound healing
Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M., Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M., Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M., Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M., Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M., Landen N.X., Landen N.X., Li D., Li D., Stahle M., Stahle M.
Differentiation of umbilical cord mesenchymal stem cells into hepatocytes in comparison with bone marrow mesenchymal stem cells
Chen Y., Qi F.-Z., Song Y., Yu Y.-B., Yu Y.-B., Zhang F., Chen Y., Qi F.-Z., Song Y., Yu Y.-B., Yu Y.-B., Zhang F.
VEGF secreted by Mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms
Chen C., Chen X., Cheng W., Dong D., Ge Q., Guo J., Hou J., Wan L., Wang X., Wu X., Xia J., Zhang H.
Indarto D., Yarso K.Y., Soetrisno S., Nugroho A.N., Wahyudi A.Z., Mudigdo A.
Peerj
Hu J.-J., Liao L.-G., Xiong Z.-G.
World Journal of Gastrointestinal Oncology
Su M., Shi J.
Biochemical Genetics
Fahmy N.T., Mohammed S.F., Badr M.S., Atta S.A., Ahmed S.G., El-Sayed S., Abd-Elhamid A.H., Mahmoud N.A., Amin M.M., Hassan Z.R., Salama D.E.A., Abdelgalil R.M., Zekry K.M., Taha A.K., Mohamed R.E., Eraque A.M.S., Mohamed S.A.
Parasitology Research
Hu J., Yang F., Yang W., Sun H., Fei Y., Guo Z.
Applied Surface Science Advances
Padalhin A., Abueva C., Ryu H.S., Park S.Y., Seo H.H., Yoo S.H., Chung P.-S., Woo S.H.
Stem Cell Research and Therapy
El Shahawy M., Badawy M., Mohammed S.A.-N., Mahmoud H.
Archives of Oral Biology
Pan H., Li Y., Richter D.M., Abd G.M., Ku J.C., Minor A., Sawyer R.G.
Journal of Surgical Research
Permatasari N., Wiyasa I.W.A., Rachmawati R., Warsan G.S.A., Larasati M.E.S., Gisma R.F.
Tropical Journal of Natural Product Research
