The Impact of Nanoparticles Saltwater Fish on Osteoblast Cells During the Alveolar Bone Formation Stages in Fetal Mice
Hutami I.R., Pradopo S., Ibrahim Z., Christiono S., Indrawati S.V., Mayangsari R.S., Arbianti K., Pratama M.D.P.
Abstract
Alveolar bone formation is important to pay attention to because disturbances in bone formation can cause tooth malposition due to suboptimal jaw development. Pregnant female mice who lack nutrition will impact the fetus’s growth and development, including the alveolar bone. One good nutrient to support alveolar bone development is saltwater fish powder nanoparticles. Seafish powder contains calcium and omega 3 for bone development, which has not been explained. This study aims to determine how giving saltwater fish powder nanoparticles to pregnant mice affects fetal mice’s alveolar bone osteoblast cells. This study used a post-test-only control group design with 12 pregnant mice. Pregnant mice were divided into 2 groups, namely the group given normal food and the group was given selfish powder nanoparticles. saltwater fish powder nanoparticles and normal feed were given 18 days during pregnancy. To see the development of the alveolar bone in the fetus of mice (mus muscullus), it was done by dissecting the fetus after 18 days of gestation. Alveolar bone development was seen from the number of osteoblasts using hematoxylin-eosin (HE) staining. The results of the Independent T-test test showed a value of p<0.05 (p=0.000) that there was a significant difference in the number of osteoblast cells between study groups. Saltwater fish powder nanoparticles in pregnant mice increased the number of osteoblast cells in the fetal alveolar bone mice.
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Christiono S., Hutami I.R., Ibrahim Z., Mayangsari R.S., Pradopo S., Rochmah Y.S., Sudiana I.K., Christiono S., Hutami I.R., Ibrahim Z., Mayangsari R.S., Pradopo S., Rochmah Y.S., Sudiana I.K., Christiono S., Hutami I.R., Ibrahim Z., Mayangsari R.S., Pradopo S., Rochmah Y.S., Sudiana I.K.
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