Hypoxic mesenchymal stem cells (MSCS)-induced interleukin (IL)-10 alleviate systemic lupus erythematosus (SLE) inflammation through inhibiting interferon (IFN)-gamma production
Wisnu Prajoko Y., Putra A., Prasetio A., Dina Amalina N.
Abstract
Aim To determine the effect of hypoxic mesenchymal stem cells (MSCs) on the interleukin (IL)-10 and interferon (IFN)-gamma in peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients. Methods This study used a post-test control group design. Hypoxic MSCs were isolated and characterized according to their surface marker expression and differentiation capacities. PBMCs isolated from SLE patients were divided into three groups: control and two treatment groups. The treatment groups were treated by co-cultu-ring MSCs to PBMCs with a ratio of 1:10 (T1) and 1:1 (T2) for 48 h incubation. Furthermore, IFN-gamma and IL-10 levels were determined by cytometric bead array (CBA) flow cytometry. Results Hypoxic MSCs significantly decreased the IFN-gamma levels and increased the IL-10 levels in dose-dependent manner compared to the control group. The highest activity of hypoxic MSCs was noticed in T2 group. Conclusion Hypoxic MSCs-induced IL-10 are important in the control of anti-inflammatory effect on SLE through inhibiting IFN-gamma.
The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses
Coleman M., Corrigan O.I., Lavelle E.C., McNeela E.A., Mori A., O'Hagan D.T., Oleszycka E., Ozasa Y., Sharp F.A., Singh M., Tajber L.
The role of TLR4 in chemotherapy-driven metastasis
Ran S.
Effect of chitosan on blood profile, inflammatory cytokines by activating TLR4/NF-κB signaling pathway in intestine of heat stressed mice
Bao M.-L., Chen S.-W., Hu C.-Y., Ju X.H., Liu X.-X., Ma X.-B., Mohyuddin S.G., Qamar A., Wen J.-Y., Wu L.-Y., Yong Y.-H., Yu Z.-C.
The CD4+CD25+FoxP3+ Regulatory T Cells Regulated by MSCs Suppress Plasma Cells in a Mouse Model of Allergic Rhinitis
Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J., Alif I., Amalina N.D., Farhat F., Ichwan M., Ilyas S., Madiadipoera T., Munir D., Putra A., Restimulia L., Sembiring R.J.
The therapeutic efficacy of mesenchymal stromal cells on experimental colitis was improved by the IFN-γ and poly(I:C) priming through promoting the expression of indoleamine 2,3-dioxygenase
Kim B.-S., Kim T.W., Lim J.-Y., Min C.-K., Park G., Ryu D.-B., Kim B.-S., Kim T.W., Lim J.-Y., Min C.-K., Park G., Ryu D.-B.
The role of tnf-α induced mscs on suppressive inflammation by increasing tgf-β and il-10
Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K.
Regulatory T cells and immune regulation of allergic diseases: Roles of IL-10 and TGF-β
Akdis C.A., Akdis C.A., Akdis M., Cavkaytar O., Cavkaytar O., Lauener R., Lauener R., Martin-Fontecha M., Palomares O., Palomares O., Traidl-Hoffmann C., Traidl-Hoffmann C., Akdis C.A., Akdis C.A., Akdis M., Cavkaytar O., Cavkaytar O., Lauener R., Lauener R., Martin-Fontecha M., Palomares O., Palomares O., Traidl-Hoffmann C., Traidl-Hoffmann C.
Hypoxia-mesenchymal stem cells inhibit intra-peritoneal adhesions formation by upregulation of the il-10 expression
Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M., Muhar A.M., Munir D., Putra A., Warli S.M.
Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
Hong S.-H., Kim B., Kim S.-Y., Kim Y.-H., Nam H.-Y., Park C.-G., Park M.-J., Shin J.-Y., Yang S.-H., Yoon I.-H., Hong S.-H., Kim B., Kim S.-Y., Kim Y.-H., Nam H.-Y., Park C.-G., Park M.-J., Shin J.-Y., Yang S.-H., Yoon I.-H., Hong S.-H., Kim B., Kim S.-Y., Kim Y.-H., Nam H.-Y., Park C.-G., Park M.-J., Shin J.-Y., Yang S.-H., Yoon I.-H.
Anti-inflammatory effects of human embryonic stem cell-derived mesenchymal stem cells secretome preconditioned with diazoxide, trimetazidine and MG-132 on LPS-induced systemic inflammation mouse model
Eslami Far A., Jahandideh S., Kadivar M., Khatami S., Eslami Far A., Jahandideh S., Kadivar M., Khatami S., Eslami Far A., Jahandideh S., Kadivar M., Khatami S.
Gao X., Ma H., Song Y., Zhu K., Xue H., Hao J., Yu K., Zhang S., Cao S., Sun Z., Liu D., Zhang X., Li W., Yang M.
Scientific Reports
Dirja B.T., Putra A., Amalina N.D., Wardoyo E.H.
Trends in Sciences
