Combination of Honey and Nigella sativa Oil Reduce Oxidative Stress and Inflammation in Unilateral Ureteral Obstruction in Rats
Sarosa H., Indrayani U.D., Utami K.D., Faidiansyah G.A., Amanda Q.
Abstract
Renal fibrosis plays a significant role in the development of chronic kidney disease (CKD). Therefore, treatment of renal fibrosis is essential in reducing the incidence of CKD-related problems. Due to their function as anti-inflammatory and antioxidant agents, honey and Nigella sativa may have therapeutic promise in renal fibrosis. This study aim to investigate the effects of the combination of honey and Nigella sativa oil as anti-inflammatory and antioxidant agents in a rat model of unilateral ureteral obstruction (UUO)-induced kidney injury. In this study, thirty male Wistar rats were divided randomly into five groups. One sham group, one UUO group, and three UUO groups that received varied doses of the combination of honey and Nigella sativa oil (HoNi). HoNi was administered to the rats orally, once daily for 21 days starting from the 14<sup>th</sup> day post-UUO induction. After treatment, blood samples were collected, and the levels of antioxidant enzymes; Superoxide Dismutase (SOD), Glutathione (GSH), and Catalase (CAT) were measured. The inflammatory marker; C-reactive protein (CRP) activity, and haemoglobin (Hb) levels were also measured. The results showed that the administration of the combination of honey and Nigella sativa for 21 days in UUO rat model significantly reduced CRP, while increasing the activities of SOD, GSH, and CAT, and also enhanced haemoglobin levels in a dose-dependent manner.These findings suggest that the renoprotective effect of the combination of honey and Nigella sativa oil maybe associated with its anti-inflammatory and antioxidant properties.
Evaluation of safety and efficacy profile of Nigella sativa oil as an add-on therapy, in addition to alpha-keto analogue of essential amino acids in patients with chronic kidney disease
Alam M.A., Haque S.F., Khan R.A., Nasiruddin M.
Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major
Aboonq M.S., Abu-el Naga M., Abu-el Naga M., Alharbi R., Almaramhy H.H., Arafa W., Attia M., Ayat M., Baghdadi H., El Sayed S.M., El Sayed S.M., El-Sawy S.A., El-Shanshory M., El-Shanshory M., Elshazley M., Elshazley M., Fakhreldin A.R., Hablas N.M., Mariah R.A., Mariah R.A., Moustafa S., Moustafa S., Nabo M.M.H., Zidan M., Zolaly M.
Role of nigella sativa and its constituent thymoquinone on chemotherapy-induced nephrotoxicity: Evidences from experimental animal studies
Amruthraj N.J., Amruthraj N.J., Arra C., Barbieri A., Bimonte S., Cascella M., Cuomo A., del Vecchio V., Falco M., Luciano A., Muzio M.R., Palma G., Rea D.
No Title
Amruthraj NJ, Barbieri A, Bimonte S, Cascella M, Del Vecchio V, Falco M, Luciano A, Muzio MR, Palma G, Rea D
Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
Asrida A, Astuti A, Leli L, Saad R.
Honey and its nutritional and anti-inflammatory value
Akim A.M., Albujja M., Bakar M.F.A., Fadel A., Hamid H.A., Khazaai H., Ranneh Y., Zakaria Z.A.
Renal injury, nephrolithiasis and Nigella sativa: A mini review
Hadjzadeh MAR., Hayatdavoudi P, Khajavi Rad A, Rajaei Z
Black cumin (Nigella sativa l.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety
Afrin T., Alam M., Alam M., Choi H.J., Dash R., Hannan M.A., Hannan M.A., Haque M.N., Hossain M.T., Jahan I., Khan M.K., Khan M.K., Kim B., Mitra S., Mohibbullah M., Moon I.S., Munni Y.A., Oktaviani D.F., Rahman M.A., Rahman M.M., Rahman M.S., Sarker P.P., Sarker P.P., Sikder M.H., Sohag A.A.M., Tahjib-Ul-arif M., Timalsina B., Uddin M.J., Uddin M.J.
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
Li F., Rajendran P., Sethi G.
IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing snail1 expression in a mouse model
Dong R., Dong R., Qian Q., Yang S., Yu F., Yu J., Zha Y., Zha Y.
Iskandar C.D., Husna F., Fajri F., Ridwan M., Fitriani F., Purnawarman A., Izzuddin A., A.yafi D., Nurkhalis N.
Tropical Journal of Natural Product Research
