Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models
Sumarawati T., Putra A., Trisnadi S., Amalina N.D., Setiawan E., Hermansyah D., Angelina J.
Abstract
Aim To investigate the effects of exosome-derived human mesenchymal stem cells (EH-MSCs) on matrix metalloproteinase-1 (MMP)-1 and malondialdehyde (MDA) levels in ultraviolet-B (UVB)-irradiated Wistar rats. Methods The study used a post-test-only control group design with randomized allocation. Thirty rats were exposed to UVB radiation (302 nm, 150 mJ/cm²) for 8 minutes, five times a week over two weeks. Five groups were established: a healthy control (G1), a negative control (G2), a positive control that received a 200 μL subcutaneous injection of hyaluronic acid (HA) (G3), a treatment group 1 that received a 200 μL subcutaneous injection of exosome-derived EH-MSCs (G4), and a treatment group 2 that received a 300 μL subcutaneous injection of EH-MSCs (G5). An ELISA was used to quantify the levels of MDA and MMP-1. Results A significant reduction in the mean level of MDA in groups G4 (368.33 ± 59.67) and G5 (329.33 ± 82.06) was noted when compared to the negative control group G2 (686.58 ± 119.01) (p<0.05). Similarly, MMP-1 showed a significant decrease in mean levels for G4 (0.08 ± 0.04) and G5 (0.07 ± 0.04) compared to G2 (0.33 ± 0.06) (p<0.05). Conclusion These findings suggest that EH-MSCs have potent antioxidant and anti-inflammatory properties, mitigating UVB-induced skin damage by reducing oxidative stress markers.
Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study
Kwon H.H., Lee J., Park B.C., Park G.-H., Park K.Y., Seok J., Shin E., Yang S.H.
The role of tnf-α induced mscs on suppressive inflammation by increasing tgf-β and il-10
Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K., Kustiyah A.R., Munir D., Putra A., Putra A., Putridewi A.I., Ridwan F.B., Rosdiana I., Sadyah N.A.C., Wirastuti K.
Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats
Abdallah S.H., Abdelalim A.F., Algendy R., Arisha A.H., Arisha A.H., Ebian H.F., Edress N.M., Hendawy D.M., Khamis T., Khamis T., Nafea A., Saeed A.A.
Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition
Duan M., Li J., Li J., Li X., Liu Y., Pan Y., Tang L., Zhang G., Zhang G., Zhang Y.
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression
Bi J., Bi J., Huo R., Huo R., Li J., Li Z., Wang S.
Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus
Astari L, Cahyono H, Widjajanto E.
Correlation of Serum Levels of Vitronectin, Malondialdehyde and Hs-CRP With Disease Severity in Coronary Artery Disease
Abolhasani S, Alikhah H, Ghojazadeh M, Khaki-Khatibi F., Yaghoubi A
The emerging antioxidant paradigm of mesenchymal stem cell therapy
Nurgali K., Nurgali K., Nurgali K., Stavely R., Stavely R.
Potential of bone marrow mesenchymal stem cells in rejuvenation of the aged skin of rats
Guan J.-Z., Hu G.-D., Jia C.-Y., Liu Z., Luo X.-B., Shu B., Yin B.
Mesenchymal stem cells decrease oxidative stress in the bowels of interleukin-10 knockout mice
Jang B.I., Jung K.J., Kim J.Y., Kim S.Y., Lee G.W., Lee T.J., Park C.H., Song I.H., Sung E.G.
