Hypoglycemic and antianemia effects of chlorophyll from sauropus androgynus (L) merr leaves in rats
Mangimbulude J.C., Martosupono M., Fasitasari M., Suparmi S.
Abstract
Background: Beneficial effect of katuk (Sauropus androgynus L Merr) leaves (CSA) as one of medicinal plant in Indonesian jamu may potential to cure diabetes mellitus (DM) and iron deficiency anemia (IDA) as well as its well-known effect to increase breast milk production. Objectives:This study was aiming to explore the hypoglycemic effects of CSA in streptozotocin-induced DM rats (STZ) and antianemia effects in IDA rats (FeD). Material and Methods: STZ male Wistar rats were treated with CSA, commercial chlorophyll (Chln) and glibencamide. Blood glucose levels and histological changes of liver, kidney and pancreas were analyzed after 14 days treatment. At separate experiment, FeD female Wistar rats were treated with CSA and Chln. The treatment was performed orally at the 1<sup>st</sup> - 20<sup>th</sup> day of pregnancy. Levels of Hb, Fe and ferritin blood serum, number and body weight of the offspring were analyzed on 21<sup>st</sup> day (post-partum). Results: Treatment of CSA for 14 days to diabetic animals demonstrated the hypoglycemic effect, however the histological analysis suggested that the scores of liver, kidney and pancreas were higher than that in the normal group. Moreover, CSA exerted a significant restorative effect by returning the levels of hemoglobin, serum iron, and serum ferritin. A fetus analysis suggested that the fetus body weight of in the CSA and Chln groups was similar to that in the normal group. Conclusion: CSA treatment are potential as a new herbal supplement to cure DM and IDA. However, the safety dose should be considered to prevent the toxicity.
Hemoglobin decrease with iron deficiency induced by daclatasvir plus asunaprevir combination therapy for chronic hepatitis c virus genotype 1b
Fukuda Y., Hattori N., Hiraishi T., Ikeda H., Ishii T., Itoh F., Matsumoto N., Matsunaga K., Noguchi Y., Okuse C., Sato A., Shigefuku R., Suzuki M., Tamura T., Watanabe T.
Effectiveness of AOS-iron on iron deficiency anemia in rats
An F., An F., He H., Huang Q., Huang Q., Jia S., Liu C., Song H., Song H., Wang Y.
Iron absorption and transport - An update
Conrad M.E., Umbreit J.N.
Anti-anemia effect of chlorophyll from katuk (sauropus androgynus) leaves on female mice induced sodium nitrite
Ednisari A.M., Laila I., Nur Anna C.S., Saintika H.R., Sampurna, Suparmi, Urfani G.D., Ednisari A.M., Laila I., Nur Anna C.S., Nur Anna C.S., Saintika H.R., Sampurna, Sampurna, Suparmi, Urfani G.D., Ednisari A.M., Laila I., Nur Anna C.S., Saintika H.R., Sampurna, Suparmi, Urfani G.D., Ednisari A.M., Laila I., Nur Anna C.S., Nur Anna C.S., Saintika H.R., Sampurna, Sampurna, Suparmi, Urfani G.D., Ednisari A.M., Laila I., Nur Anna C.S., Saintika H.R., Sampurna, Suparmi, Urfani G.D.
Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis
Mander A.P., Pereira D.I.A., Powell J.J., Stecher L., Tolkien Z., Mander A.P., Pereira D.I.A., Powell J.J., Stecher L., Stecher L., Tolkien Z., Tolkien Z.
Daily oral iron supplementation during pregnancy.
De-Regil L.M., Dowswell T., Pena-Rosas J.P., Viteri F.E.
Antioxidant effects of chlorophyll and pheophytin on the autoxidation of oils in the dark. II. The mechanism of antioxidative action of chlorophyll
Endo Y., Kaneda T., Usuki R., Endo Y., Kaneda T., Usuki R.
Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats
Gabhe S.Y., Jaiswal Y.S., Tatke P.A., Vaidya A.B.
Trigonella foenum-graecum seeds extract plays a beneficial role on brain antioxidant and oxidative status in alloxan-induced Wistar rats
Bhaskar M., Nandyala V.S., Pradeepkiran J.A., Pradeepkiran J.A.
Effects of Chlorophyll in Papaya Leaves on Superoxide Dismutation and Blood Glucose Level of Diabetic Rats
Kartasurya MI, Nissa C, Rahmawati B.
Koyama T., Gu Y., Liu X., Zhang R., Xu W.
Lwt
Rustanti N., Fasitasari M., Suparmi S., Latifah F., Lestanu L.A., Wahyudi D.P.A.S., Ifroza L., Taufiqurrokhim N.H., Irmadhani D.
Brazilian Journal of Biology
Anju T., Rai N.K.S.R., Kumar A.
Journal of Ethnic Foods
Gumilang L., Novianti E., Adnani Q.E.S., Oktavia D., Sunardi
Biodiversitas
Zheng C., Jiang S., Ruan D., Zhang S., Lin X., Cheng J., Ding F., Ye J., Liu J., Liu P.
Chinese Journal of Animal Nutrition
Capanoglu E., Ozdal T., Kamiloglu S., Tomas M., Gunal-Koroglu D.
Phytochemistry Reviews
Rustanti N., Fasitasari M., Suparmi S., Latifah F., Lestanu L.A.
Journal of Pharmacy and Pharmacognosy Research
