High-Fat Diet Decreases Serum TNF-Alpha and Breast Tumor Area on Benzopyrene Induced Mice (Mus Musculus)
Fasitasari M., Rejeki P.S., Pranoto A., Sukarno D.A., Izzatunnisa N., Utami D.M.
Abstract
This study aims to analyze whether the high-fat diet decreases serum TNF-α and breast tumor area on benzopyrene induced mice (Mus musculus). This study was a true experimental with the randomized posttest-only control group design using 36 female mice (Mus musculus), 3-4 months age, 25 ± 5 grams. Mice were induced with benzopyrene (BZP) subcutaneously with a dose of 0.3mg/20gBB/day for 14 days in the right breast area, then randomly divided into 6 groups, Ki (negative control group, given standard feed), K2 (positive control group, standard feed), K3 (high-fat diet with a ratio of 60% protein, 0% carbohydrate, 30% fat, 10% fiber), K4 (high-fat diet with a ratio of 45% protein, 0% carbohydrate, 45% fat, 10% fiber), K5 (high-fat diet with a ratio of 30% protein, 0% carbohydrate, 60% fat, 10% fiber) and Kg (high-fat diet on day 15 with a ratio of 15% protein, 0% carbohydrate, 75% fat, 10% fiber). The high-fat diet was administered for 28 days. The mean of tumor area delta at K1 (0.00 ± 0.00) mm<sup>2</sup>, K2 (3.52 ± 1.98) mm<sup>2</sup>, K3 (27.18 ± 21.23) mm<sup>2</sup>, K4 (13.19 ± 9.93) mm<sup>2</sup>, K5 (8.80 ± 1.72) mm<sup>2</sup>, K6 (10.81 ± 6.55) mm<sup>2</sup>, and (p=0.001). The mean of TNFc levels at K1 (56.32 ± 8.25) ng/mL, K2 (65.99 ± 2.82) ng/mL, K3 (70.43 ± 4.61) ng/mL, K4 (58.05 ± 5.80) ng/mL, K5 (54.91 ± 3.27) ng/mL, Kg (59.67 ± 3.63) ng/mL and (P = 0.000). A high-fat diet lowers TNFc levels and reduces the area of BZP-induced breast tumors. The lowest TNFc levels and the lowest breast tumor area were found in groups with a fat: protein ratio = 60:30.
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