Comparative efficacy of non-pharmacological interventions involving parent on pain during invasive procedure among preterm baby: A systematic review and network meta-analysis
Rustina Y., Kurniawati W., Efendi D., Hasan F., Chipojola R., Hasanul Huda M., Hendarwan H., Su'udi A., Adawiyah R., Susanto H., Eka Putra H.
Abstract
Background: The efficacy of various non-pharmacological interventions involving parents to reduce preterm infants’ pain during invasive procedures remains unclear. This systematic review and network meta-analysis aimed to compare their effectiveness. Methods: We conducted a systematic search across eight databases (PubMed, ScienceDirect, CINAHL, Embase, Scopus, SAGE Journals, Cochrane Central, ClinicalKey). The analysis used GeMTC software for network meta-analysis. Results: A total of 22 RCTs including 2036 participants were included. Kangaroo mother care (KMC) significantly reduced pain responses (SMD: 1.4; 95 % CI: −2.3 to - 0.61). KMC ranked highest among all interventions for alleviating pain during procedures such as heel lancing, venipuncture, and cannulation. Conclusions: While KMC appears to be the most effective non-pharmacological intervention to reduce pain in preterm infants compared to standard care, further high-quality studies are needed to confirm these findings.
