Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats
Mangimbulude J.C., Martosupono M., Fasitasari M., Suparmi S.
Abstract
Sodium nitrate (NaNO<inf>2</inf>) widely used as food additive for coloring and preserving meat has been reported to induce oxidative stress and cause histopathologic changes, nitrosative tissue damage, and lipid peroxidation in liver and kidney. Therefore, the present study compared the curative effect of chlorophyll from Sauropus androgynus (L) Merr and Cu-chlorophyllin as antioxidant in NaNO<inf>2</inf>-induced female Wistar rats based on haematological, serum biochemical, and histological evaluation. Thirty male Wistar rats were randomly assigned into six groups of five rats each. NaNO<inf>2</inf> were given at a subacute dose of 50 mg/kg bw intraperitoneally for 10 days. Chlorophyll from S. androgynus and Cu-chlorophyllin from K-Liquid™ were given in the following 14 days at the two doses: 0,016 mg/mL and 0.008 mg/mL. NaNO<inf>2</inf> exposure resulted in significant reductions (p<0.05) in values of packed cell volume (PCV), haemoglobin (Hb) concentration and red blood cell (RBC) count, transferrin, and ferritin and elevation in malondialdehyde (MDA) level and schistocytes percentage with insignificant reductions in serum albumin and transferrin levels. Histology of kidney and liver were changed insignificantly (p>0.05) to normal values. Chlorophyll from S. androgynus and Cu-chlorophyllin possess antioxidant potentials to protect against toxicities induced by sodium nitrate.
Comparative study of biological activity of three commercial products of Sasa senanensis Rehder leaf extract
Iwamoto S., Kanamoto T., Kitajima M., Matsuta T., Morita Y., Nakashima H., Ohkubo A., Oizumi H., Oizumi T., Sakagami H., Satoh K., Satoh K., Shimada C., Sunaga K., Terakubo S., Tsuda T.
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
Dinkova-Kostova A.T., Egner P.A., Fahey J.W., Fahey J.W., Fahey J.W., Kensler T.W., Stephenson K.K., Talalay P., Talalay P.
Chlorophyll-Its therapeutic place in acute and suppurative disease. Preliminary report of clinical use and rationale
Gruskin B.
Assessment of degradation and intestinal cell uptake of carotenoids and chlorophyll derivatives from spinach puree using an invitro digestion and Caco-2 human cell model
Failla M.L., Failla M.L., Ferruzzi M.G., Schwartz S.J.
Analysis of the therapeutic effect of sodium copper chlorophyllin tablet in treating 60 cases of leukopenia
Gao F., Hu X.-F.
Nitrite-induced iron deficiency in the neonatal rat
Kate Smith M., Roth A.C.
L-Arginine and l-glutamine as immunonutrients and modulating agents for oxidative stress and toxicity induced by sodium nitrite in rats
El-Sheikh N.M., Khalil F.A.
Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors-induced liver injury and oxidative stress in male rats
Hassan H.A., Yousef M.I.
Dietary vitamin E and selenium and toxicity of nitrite and nitrate
Chow C.K., Hong C.B.
Rapid oxidative stress induced by N-nitrosamines
Ahotupa M., Bartsch H., Bereziat J.-C., Bussacchini-Griot V., Camus A.-M.
