Treatment of thyponium flageliforme in combination with Curcuma Zedoaria, and phyllanthus niruri synergistically enhances apoptotic and anti-proliferative effect on breast cancer
Widayati E., Chodidjah, Nasihun T.
Abstract
Introduction: Breast cancer is the most common cancer and the second leading cause of cancer death in women. Combinations of Thyponium flageliforme, Curcuma zedoaria and Phyllanthus niruri (TCP) have been proven as immuno-modulator and retarded tumor progression in vivo. Objective: to investigate the apoptotic and anti-proliferative effect of TCP in C3H mice suffered from adenocarcinoma cells. Methods: 18 mice inoculated with one million cells of breast adenocarcinoma per mouse were assigned into three groups, TCP with dosage 85 and 125 mg were treated for 21 days to evaluate tumor volume, expression of Ki-67 and Capase3. Expression of Ki-67 and Capase3 were measured by immunohistochemistry staining, whilst cancer volume was assessed using calipers. Results: Mann Whitney analysis indicated that tumor volume in TCP groups were lower, otherwise for expression of caspase<inf>3</inf>, p < 0.05 respectively. Whereas expression of Ki-67 in TCP groups was lower, but not significant, p > 0.05. Conclusion: TCP treatment with 85 and 125 mg dosage capable of reducing tumor volume, increasing caspase<inf>3</inf> and lowering Ki-67 expression.
Chemical constituents and anticancer activity of Curcuma zedoaria roscoe essential oil against non-small cell lung carcinoma cells in vitro and in vivo
Chang C.-S., Chen C.-C., Chen Y., Ho C.-T., Hsi Y.-T., Huang L.-F., Kao J.-Y., Way T.-D., Way T.-D., Way T.-D.
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
Debatin K.-M., Fulda S.
Gurmeet. Typhonium flagelliforme: A multipurpose plant
Deepak S., Dinesh K., Mankaran S., Kumar D, Mankaran S, Sharma D, Singh G.
Cytotoxic activity from Curcuma zedoaria through mitochondrial activation on ovarian cancer cells
Lee Y., Shin Y.
No Title
Malek A.S.N., Rahman A.S.M., Wahab A.N.
Emerging roles of caspase-3 in apoptosis
Janicke R.U., Porter A.G.
Administration of purwoceng (Pimpinellaalpina Molk) improves oxidative stress biomarker following UVC irradiationin Spargue-Dawley male rats
Nasihun T., Widayati E.
Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test
Dos Santos L.C., Resende F.A., Varanda E.A., Vilegas W., Dos Santos L.C., Resende F.A., Varanda E.A., Vilegas W.
"A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies"
Carrier L., Marsden C.G., Moroz K., Pochampally R., Rowan B.G., Wright M.J.
Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: Model characterisation and in vivo effects of ibandronate on tumour growth
Bauss F., Bauss F., Fischer C., Krempien B., Neudert M., Seibel M.J.
