Potential immuno-modulatory activity of probiotics containing Lactobacillusacidophilus and Lacobacilluscasei to increase the ratio of IFN γ/IL-4 in patients with allergic rhinitis
Fatmawati D., Wiratn, Wardani A.T.W.
Abstract
Aims: This study aimed to determine the effect of probiotic combination on ratio of IFN-γ: IL-4 levels in patients with allergic rhinitis. Materials and methods: Single blind, randomized controlled trial.This study included 40 patients with severe allergic rhinitis according to WHO criteria. This study used 2 treatment groups with probiotics and placebo control group. IFN γ and IL-4 levels were evaluated using ELISA method. Data were analyzed using paired T test with 95% confidence intervals. Results and Discussion: In the treatment group, the levels of IFN-γ increased significantly (p<0.05).In contrast, IL-4 levels decreased significantly(p<0.05). There was a significant difference between the IFN-γ ratio: IL-4 treatment and control group (p <0.05). Conclusion: The administration of combination of probiotics can improve the levels of IFN-γ/ IL-4 in patients with moderate to severe allergic rhinitis.
Chapter 22. Strategies for early prevention of allergic disorders
Gruber C., Hamelmann E., Illi S., Lau S., Nickel R., Wahn U.
Prospek Prebiotik Dalam Pencegahan Alergi Melalui Induksi Toleransi Aktif Imunologis
Endaryanto A., Harsono A.
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
Akira S., Nakao A., Ogawa H., Okumura K., Ra C., Supajatura V., Ushio H.
Toll-like receptor control of the adaptive immune responses
Iwasaki A., Medzhitov R.
No Title
Mohamadzadeh M.
Bacterial teichoic acids reverse predominant IL-12 production induced by certain lactobacillus strains into predominant IL-10 production via TLR2-dependent ERK activation in macrophages
Kaji R., Kiyoshima-Shibata J., Nagaoka M., Nanno M., Shida K.
Rian. Pengaruh Pemberian Yogurt Terhadap Kadar IgE
Wardani A.T.
Evaluation of immunomodulation by Lactobacillus casei Shirota: Immune function, autoimmunity and gene expression
Baken K.A., de Klerk A., Ezendam J., Gremmer E.R., Matthee B., Peijnenburg A.A.C.M., Pennings J.L.A., van Loveren H.
Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019)
Gill H.S., Gopal P.K., Prasad J., Rutherfurd K.J.
The role of Probiotics in allergic diseases
Michail S.
