The effects comparisons of sauropus androgynous, moringa Oleiefera alone and in combination on iron deficiency in anemia rats
Hussaana A., Sarosa H., Widiyanto B., Indrayani U.D.
Abstract
Background: Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The combination of the two extracts have been known to potentially have a synergistic effect on anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats. Methods: Thirty female wistarstrain rats were randomly divided into 5 groups: normal, iron deficiency anemia, Sa, Mo and the combination of Sa and Mo. Beside the normal group, rats were fed Fe-deficient diet to induce iron-deficiency anemia. Level of hemoglobin, ferritin and plasma MDA were measured on day 8 (after induction of anemia) and day 29. Data were analyzed using One Way ANOVA followed by LSD post hoc test. Result: The rats fed with Fe-deficient diet for 7 days shown significantly had a lower plasma Hb and ferritin levels and higher plasma MDA levels compared to the normal group (p <0.05) After the treatment, the rats given the extracts significantly had a higher mean of Hb and Ferritin and a lower mean of MDA level compared to anemic control. The mean Hb, ferritin and MDA level of the combination group were close to normal group. Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.
No Title
Adnan M., Ahmad S.M., Article O., Islam N., Zaka-Ur-rab Z.
Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death
Lang E., Lang F.
Impaired red cell deformability in iron deficient subjects
Brandaeo M.M., Cesar C.L., Costa F.F., De Castro M.L.R.B., Fontes A., Saad S.T.O.
Effect of oxidative stress on membrane proteins in thalassemia and iron deficiency anemia
Aksoy K., Yuzbasioglu Ariyurek S.
No Title
Achem L., Emilse M., Jimenez C.L., Lazarte S.S., Monaco M.E., Teran M.M.
No Title
Aa A., Ga A., Om J., Ts E.
Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity
Padma P.R., Sreelatha S.
Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera
Dhakarey R., Prakash D., Singh B.N., Singh B.R., Singh H.B., Singh R.L., Upadhyay G.
Nutritive value of Sauropus androgynus leaves
Padmavathi P., Rao M.P.
Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats
Giridhar P., Manoj P., Saini R.K., Shetty N.P., Srinivasan K.
