Protective effect of bixin isolated from Bixa orellana L. Seeds on UVB-induced inflammation and immunosuppression of the skin
Suparmi, Hussaana A., Murti H.A.
Abstract
Background: DNA damage caused by excessive ultraviolet B (UVB) radiation on the skin triggers the response to inflammatory and immunosuppression. The bixin from Bixa orellana L. has been proven to be able to inhibit cyclo-oxygenase. Objective: to verify whether the bixin lotion has the effect to offer protection against inflammation and immunosuppression due to acute UVB irradiation in shaved BALB /c mice. Methods: Protection against inflammation and immunosuppression, respectively were studied in 4 groups of mice. Each group was treated respectively with topical application of base lotion as a control; bixin lotion doses of 0.5 mg; 2.5 mg and 125 mg, for 10 days prior to and during the UVB irradiation. The Inflammation was induced by UVB irradiation, 360 mJ/cm2 once a day for 3 consecutive days, whereas the immunosuppression was induced by UVB irradiation, 360 mJ/cm2 once a day for 5 consecutive days. The inflammatory response was measured as an increase in middorsal skinfold thickness at the peak response. The immune response was measured as the contact hypersensitivity (CHS) response to oxasolon sensitization. Results: The results indicated that in concentration range used, bixin lotion significantly decreased the middorsal skinfold thickness at 72 hours after UVB radiation (p <0.05) compared to the control, but there was no significant difference between couples of the dose of bixin. Bixin lotion was also capable to restore the suppression of CHS from 34.22% in the control group to 11.4%; 0.5% and 0% at doses of 0.5; 2.5 and 125 mg respectively (p <0.05). Conclusion: Bixin lotion has the potential to reduce the inflammatory edema reaction and the suppression of CHS of mice induced by UVB radiation.
Mirabilis Jalapa L. Protein as inductor of apoptosis on UVB-induced skin damage in mice
Hussaana A., Ikawati Z., Sismindari, Sudjadi, Widyarini S., Hussaana A., Ikawati Z., Sismindari, Sudjadi, Widyarini S.
In vitro antioxidant activity of Bixa orellana (Annatto) seed extract
Abayomi M., Adebayo A.S., Bennett D., Porter R., Shelly-Campbell J.
Oxidative damage and carcinogenesis
Strzelczyk J.K., Wiczkowski A.
COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn
Kudva S., Murphy S.A., Nicolaou A., Pilkington S.M., Rhodes L.E.
Phytochemistry, biological activities and potential of annatto in natural colorant production for industrial applications - A review
Mohammad F., Rather L.J., Shahid-ul-Islam
Achiote (Bixa orellana L.): a natural source of pigment and vitamin E
Carrari F., de Leon-Sanchez F.D., Godoy-Hernandez G., Mendoza-Espinoza J.A., Perez-Flores L.J., Pinzon-Lopez L.L., Raddatz-Mota D., Rivera-Cabrera F.
Photoimmunology
Cala C.M., Elmets C.A., Xu H.
UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28
Bode A.M., Dong Z., Dong Z., Keum Y.-S., Keum Y.-S., Kim H.-G., Surh Y.-J.
The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis
Bowden N.A., Budden T.
Association between Oxidative DNA Damage and Risk of Colorectal Cancer: Sensitive Determination of Urinary 8-Hydroxy-2′-deoxyguanosine by UPLC-MS/MS Analysis
Guo C., Li X., Mao L., Mao L., Mao L., Wang R., Wang R., Ye M., Ye M., Ye M., Yu J., Yu J., Zhang S., Zhang S., Zheng S., Zheng S.
