Association between maternal folate intake and polymorphism MTHFR A1298C as risk factor of non-syndromic cleft lips
Rajiani I., Sosiawan A., Rochmah Y.S., Harumsari S.
Abstract
Background: Methylenetetrahydrofolate reductase (MTHFR) is often associated with the incidence of orofacial clefts. Folic acid deficiency has gained considerable attention because of its promising role in modulating diverse clinical condition such as cleft. The objective of the study is to describe the association of MTHFR A1298C polymorphism and maternal folate intake with an orofacial cleft in Sasak Population. Method: This study used control case design, the number of the subjects were 148 who were divided into case groups and their mother (70 issues) and control groups and their mother (78 items). The detection of Polymorphism MTHFR A1298C used PCR-RFLP and sequencing for confirmation. The information on the dietary pattern and folic acid intake used FFQ (Food Frequency Questionnaire). Results: MTHFR A1298C polymorphism was associated with maternal folic acid intake in Sasak (p = 0,001), OR = 14,7 CI 95% (2,49-85,53) for cases and (p= 0,041), OR = 4,4 CI 95%(0,9-19,16) for control group. Maternal folic acid intake was associated with cleft (p=0,037) OR= 2,7 CI 95% (1,06-6,94) in Sasak Population. Conclusion: Maternal folic acid was as the risk factor cleft lip/palate in Sasak population and association with MTHFR A1298C Polymorphism.
Folate intake, markers of folate status and oral clefts: Is the evidence converging?
Johnson C.Y., Johnson C.Y., Little J., Little J.
Genetics of cleft lip and cleft palate
Leslie E.J., Leslie E.J., Marazita M.L., Marazita M.L., Marazita M.L.
Folic acid supplementation in pregnancy and implications in health and disease
Barua S., Junaid M.A., Kuizon S.
Relationship to Folate Status and Effect of Supplementation
Carolyn T., Deborah C., Gideon K.
Impact of folate and homocysteine metabolism on human reproductive health
Alberto J.M., Daval J.L., Forges T., Forges T., Gueant J.L., Gueant-Rodriguez R.M., Monnier-Barbarino P., Monnier-Barbarino P.
The genetics and epigenetics of orofacial clefts
Spritz R.A.
Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country
Acuna-Gonzalez G., Acuna-Gonzalez G., Escoffie-Ramirez M., Hernandez-Romano J., Islas-Marquez A.J., Marquez-Corona M.L., Maupome G., Maupome G., Medina-Solis C.E., Villalobos-Rodelo J.J.
Perinatal characteristics among early (10-14 years old) and late (15-19 years old) pregnant adolescents
Alves J.G.B., Cisneiros R.M.R., Dutra L.P.F., Pinto R.A.
Modifying Effect of Prenatal Care on the Association Between Young Maternal Age and Adverse Birth Outcomes
Aguiar F.P., Brandao E.R., Camargo K.R., Coeli C.M., Pinheiro R.S., Vieira C.L.
Effect of maternal age and growth on placental nutrient transport: Potential mechanisms for teenagers' predisposition to small-for-gestational-age birth?
Baker P.N., Challis J.R.G., Challis J.R.G., Greenwood S.L., Hayward C.E., Jones R.L., Sibley C.P.
