The Effect of Snail Mucus (Achatina Fulica) Toward The Activity and Chronicity Indices of Renal Histology in Pristane-Induced Lupus Nephritis Mice Model
Budiningsih F., Nurudhin A., Widyastuti R., Werdiningsih Y., Prabowo N.A., Maharani T., Karyawinara A.
Abstract
Background: Snail mucus (Achatina Fulica) has been known to contain heparan sulfate, and acharan sulfate, a glycosaminoglycan with anti-inflammatory properties and might repair the injured glomeruli. Aim: This study aims to find the effect of snail mucus on activity and chronicity indices of renal histology in a pristane-induced lupus nephritis mice model. Method: This was an experimental study with a post-test-only control group design using 42 mice strains Balb/C. Mice were randomized into six groups: control, lupus nephritis, methylprednisolone, snail mucus 0.5 ccs, snail mucus 0,5 cc and methylprednisolone, and snail mucus one cc and methylprednisolone group. Result: Snail mucus significantly affected the activity index (p = 0.001). The lowest activity index was shown by snail mucus one cc and methylprednisolone group. While the chronicity index was not significantly affected by the snail mucus with p = 0.195. Snail mucus decreases the activity index of renal histology in the pristane-induced lupus nephritis mice model but not the chronicity index.
Nutritional and toxicological analysis of phoenix dactylifera (Date palm) powder used as a drink
Imran H., Jamil K., Rauf M., Rehman A., Saleem N., Sohail T., Yaqeen Z., Imran H., Jamil K., Rauf M., Rehman A., Saleem N., Sohail T., Yaqeen Z.
Studies to determine antidiarrhoeal and spasmolytic activities of extract of aegle marmelos. L fruit
Imran H., Khatoon A., Rahman A., Sohail T., Taqvi S.I.H., Versiani M.A., Imran H., Khatoon A., Rahman A., Sohail T., Taqvi S.I.H., Versiani M.A.
Comperative phyto toxicological and anti inflammatory effects of leaves extracts of holoptelea integrifolia
Abrar H., Fatima K., Khalid S., Perveen R., Rizwani G.H., Yasin H., Abrar H., Fatima K., Khalid S., Perveen R., Rizwani G.H., Yasin H.
Predictors of increase in chronicity index and of kidney function impairment at repeat biopsy in lupus nephritis
Banfi G., Calatroni M., Calatroni M., Frontini G., Moroni G., Moroni G., Ponticelli C., Porata G., Raffiotta F., Reggiani F., Reggiani F.
Chronicity index, especially glomerular sclerosis, is the most powerful predictor of renal response following immunosuppressive treatment in patients with lupus nephritis
Choi S.-E., Choi Y.-D., Kang J.-H., Lee J.S., Lee K.-E., Lee S.-S., Park D.-J., Xu H.
Vascular Endothelial Growth Factor in Systemic Lupus Erythematosus in Correlations with Disease Activity and Nailfold Capillaroscopic Changes
El-Asfahani MA., Hamoda RM, Hamza SMH, Khalil NS
Mining invertebrate natural products for future therapeutic treasure
Park Y.
Snail mucus suppresses anti dsDNA antibodies in lupus mice
Nurudhin A., Prabowo N.A., Ramadhani A.
Heparan sulfate as a regulator of inflammation and immunity
Collins L.E., Troeberg L.
Heparin/heparan sulphate interactions with complement - A possible target for reduction of renal function loss?
Daha M.R., Navis G.J., Richter M.K.S., Seelen M.A., Talsma D., Van Den Born J., Zaferani A.
Maly J., Liegertova M.
ACS Biomaterials Science and Engineering
Pratiwi D., Werdiningsih Y., Nareswari K.P., Matea A., Aryani N.D.
Bangladesh Journal of Medical Science
Alogna A., Liboni A., Rizzo R.
Biology
