The cardioprotective effect of Thymoquinone in Lipopolysaccharide-induced Sprague Dawley Mice (LPS: Induction study of an acute myocardial infarction model)
Soetrisno, Paramasari D., Abduh M.S., Purwanto B.
Abstract
Myocardial infarct induction in rat models with isoproterenol is a standard in cardioprotective research on various test substances. The other myocardial infarct induction model uses Lipopolysaccharide (LPS). LPS and isoproterenol show the same induction mechanism on myocardial damage, that is disturbed balance in free radical formation and antioxidative resistance system. This research aims to examine thedifference between LPS and Isoproterenol injections in rat models by fibrosis area. This research used a posttest-only control group design with 15 Sprague Dawley rats as samples which were divided into four groups: NaCl control group, LPS 10 mg/mL group, LPS 15 mg/mL group, and isoproterenol group. The LPS and isoproterenol groups were respectively given intraperitoneal injection with LPS and isoproterenol for 14 days, while the control group was not given any treatment. On day 15, they were terminated and measured histopathologically for fibrosis area using a micrometer. This research showed that the groups administered with LPS 10 mg/mL and 15 mg/mL resulted in myocardial infarcts of 51.910 mm2 and 102.512 mm2, respectively, while the group administered with isoproterenol resulted in myocardial infarct of 21.190 mm2. This research showed that LPS 15mg/mL induction is relevant for the development of animal models with Acute Myocardial Infarction.
Hydrogen inhibits isoproterenol-induced autophagy in cardiomyocytes in vitro and in vivo
Li A., Long Z., Tan S., Wang L., Wang T., Xu J., Zhang N., Zhang Y.
Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats. Bulletin of Faculty of Pharmacy
El-Brairy A.I., Kenawy S.A., Zaafan M.A., Zaki H.F.
Ergosterol Attenuates LPS-Induced Myocardial Injury by Modulating Oxidative Stress and Apoptosis in Rats
Lin C., Liu Z., Lu C., Wang T., Xu J., Zhang P., Lin C., Liu Z., Lu C., Wang T., Xu J., Zhang P.
Metabolic Adaptation Establishes Disease Tolerance to Sepsis
Bauer M., Blankenhaus B., Cardoso S., Carlos A.R., Del Barrio L., Larsen R., Lindig S., Mithieux G., Moita M.R., Rajas F., Rebelo S., Schauble S., Singh S., Soares M.P., Weis S., Weis S.
Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells
Sheng C., Su Q., Yao J.
Karakteristik dan perjalanan penyakit pasien infark miokard akut dengan elevasi segmen ST (IMA-EST) tanpa tatalaksana reperfusi pada rumah sakit perifer
Simanungkalit A.P., Supit A.I.
Cost-Effectiveness of Domestic PD-1 Inhibitor Camrelizumab Combined With Chemotherapy in the First-Line Treatment of Advanced Nonsquamous Non–Small-Cell Lung Cancer in China
Qiao L., Tan C., Zeng X., Zhou Z.
Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations
Neri M., Pomara C., Riezzo I., Schiavone S., Turillazzi E.
Bacopa monniera extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway
Anand T., Khanum F., Mohan Manu T., Patil M.M., Sharath Babu G.R.
Mechanisms involved in lipopolysaccharide derived ROS and RNS oxidative stress and septic shock
Hargis B.M., Hernandez-Velasco X., Kallapura G., Pumford N.R., Tellez G.
